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poly(adp-ribose) polymerase inhibitor
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Person
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doc. RNDr. Jakub Hofman Ph.D.
Academic staff at Faculty of Pharmacy in Hradec Králové
3 classes
37 publications
Classes
class
Current Strategies in Pharmacotherapy
GAF360 |
Faculty of Pharmacy in Hradec Králové
class
Current strategies in pharmacotherapy
+1
GAPS016 |
Faculty of Pharmacy in Hradec Králové
Publications
publication
Olaparib Synergizes the Anticancer Activity of Daunorubicin via Interaction with AKR1C3
2020 |
Faculty of Pharmacy in Hradec Králové
publication
Tazemetostat synergistically combats multidrug resistance by the unique triple inhibition of ABCB1, ABCC1, and ABCG2 efflux transporters in vitro and ex vivo
2023 |
Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
publication
Sonidegib potentiates the cancer cells' sensitivity to cytostatic agents by functional inhibition of ABCB1 and ABCG2 in vitro and ex vivo
2022 |
Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
publication
Talazoparib Does Not Interact with ABCB1 Transporter or Cytochrome P450s, but Modulates Multidrug Resistance Mediated by ABCC1 and ABCG2: An in Vitro and Ex Vivo Study
2022 |
Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
publication
Encorafenib Acts as a Dual-Activity Chemosensitizer through Its Inhibitory Effect on ABCC1 Transporter In Vitro and Ex Vivo
2022 |
Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
publication
Dabrafenib inhibits ABCG2 and cytochrome P450 isoenzymes; potential implications for combination anticancer therapy
2022 |
Faculty of Pharmacy in Hradec Králové
publication
Alisertib shows negligible potential for perpetrating pharmacokinetic drug-drug interactions on ABCB1, ABCG2 and cytochromes P450, but acts as dual-activity resistance modulator through the inhibition of ABCC1 transporter
2022 |
Faculty of Pharmacy in Hradec Králové
publication
Bruton's Tyrosine Kinase Inhibitor Zanubrutinib Effectively Modulates Cancer Resistance by Inhibiting Anthracycline Metabolism and Efflux
2022 |
Faculty of Pharmacy in Hradec Králové
publication
Isocitrate dehydrogenase 2 inhibitor enasidenib synergizes daunorubicin cytotoxicity by targeting aldo-keto reductase 1C3 and ATP-binding cassette transporters
2022 |
Faculty of Pharmacy in Hradec Králové
publication
Tepotinib Inhibits Several Drug Efflux Transporters and Biotransformation Enzymes: The Role in Drug-Drug Interactions and Targeting Cytostatic Resistance In Vitro and Ex Vivo
2021 |
Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
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