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Multi-target directed ligand
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prof. PharmDr. Jana Žďárová Karasová Ph.D.
External academic staff at Faculty of Medicine in Hradec Králové
44 publications
Publications
publication
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease
2019 |
Faculty of Medicine in Hradec Králové, Central Library of Charles University
publication
Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition
2024 |
Faculty of Science, First Faculty of Medicine, Third Faculty of Medicine
publication
The measured CSF/plasma donepezil concentration ratio but not individually measured CSF and plasma concentrations significantly increase over 24 h after donepezil treatment in patients with Alzheimer's disease
2023 |
Faculty of Medicine in Hradec Králové, Second Faculty of Medicine
publication
The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs
2023 |
Faculty of Medicine in Hradec Králové, First Faculty of Medicine
publication
Effect of ketamine, an NMDA-receptor antagonist, on gastric myoelectric activity in experimental pigs
2022 |
Faculty of Medicine in Hradec Králové, First Faculty of Medicine
publication
UHPLC-HRMS study of pharmacokinetics of a novel hybrid cholinesterase inhibitor K1234: A comparison between in silico, in vitro and in vivo data
2022 |
Faculty of Medicine in Hradec Králové
publication
A systematic evaluation of the cucurbit[7]uril pharmacokinetics and toxicity after a single dose and short-term repeated administration in mice
2022 |
Publication without faculty affiliation
publication
Toxicity, pharmacokinetics, and effectiveness of the ortho-chlorinated bispyridinium oxime, K870
2022 |
Publication without faculty affiliation
publication
The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-O-desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs
2021 |
Faculty of Medicine in Hradec Králové, Faculty of Pharmacy in Hradec Králové
publication
Tacrine and its 7-methoxy derivate; time-change concentration in plasma and brain tissue and basic toxicological profile in rats
2021 |
Faculty of Medicine in Hradec Králové
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