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donepezil
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prof. PharmDr. Jana Žďárová Karasová Ph.D.
External academic staff at Faculty of Medicine in Hradec Králové
44 publications
Publications
publication
The measured CSF/plasma donepezil concentration ratio but not individually measured CSF and plasma concentrations significantly increase over 24 h after donepezil treatment in patients with Alzheimer's disease
2023 |
Faculty of Medicine in Hradec Králové, Second Faculty of Medicine
publication
The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-O-desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs
2021 |
Faculty of Medicine in Hradec Králové, Faculty of Pharmacy in Hradec Králové
publication
Donepezil and Rivastigmine: Pharmacokinetic profile and brain-targeting after intramuscular administration in rats
2020 |
Publication without faculty affiliation
publication
The New Acetylcholinesterase Inhibitors PC-37 and PC-48 (7-Methoxytacrine-Donepezil-Like Compounds): Characterization of Their Metabolites in Human Liver Microsomes, Pharmacokinetics and In Vivo Formation of the Major Metabolites in Rats
2018 |
Faculty of Medicine in Hradec Králové
publication
1-Benzyl-4-methylpiperidinyl moiety in donepezil: The priority ticket across the blood-brain-barrier in rats
2018 |
Publication without faculty affiliation
publication
Concentration of Donepezil in the Cerebrospinal Fluid of AD Patients: Evaluation of Dosage Sufficiency in Standard Treatment Strategy
2017 |
Faculty of Medicine in Hradec Králové, Second Faculty of Medicine
publication
An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study
2016 |
Publication without faculty affiliation
publication
Cholinergic properties of new 7-methoxytacrine-donepezil derivatives
2015 |
Faculty of Science
publication
Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition
2024 |
Faculty of Science, First Faculty of Medicine, Third Faculty of Medicine
publication
The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs
2023 |
Faculty of Medicine in Hradec Králové, First Faculty of Medicine
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