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DNA ADDUCTS
Person
Class
Person
Publication
Programmes
prof. RNDr. Jiří Hudeček CSc.
Academic staff at Faculty of Science
3 classes
123 publications
Classes
class
Structure of biopolymers
MC250P10 |
Faculty of Science
class
Hemeproteins and metalloproteins
MC250P11 |
Faculty of Science
class
Life - Molecules and Biochemistry
MC250P70 |
Faculty of Science
Publications
publication
Cytochrome b(5) shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy
2011 |
Faculty of Science
publication
Comparison of activation of aristolochic acid I and II with NADPH:quinone oxidoreductase, sulphotransferases and N-acetyltranferases
2011 |
Faculty of Science
publication
Isolation and partial characterization of the adduct formed by 13-hydroxyellipticine with deoxyguanosine in DNA
2008 |
Faculty of Science
publication
Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse
+1
2008 |
Faculty of Science
publication
The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity
2008 |
Faculty of Science
publication
The anticancer drug ellipticine is a potent inducer of rat cytochromes P450 1A1 and 1A2, thereby modulating its own metabolism
2007 |
Faculty of Science
publication
Oxidation of ellipticine by human and rat cytochromes P450 correlates with its binding to DNA
2007 |
Faculty of Science
publication
Kinetics of 3-aminobenzanthrone oxidation by rat hepatic microsomes
2007 |
Faculty of Science
publication
Comparison of the cytotoxicity of and DNA adduct formation by the anticancer drug ellipticine in human breast adenocarcinoma, leukemia and neuroblastoma cells
2007 |
Faculty of Science
publication
The effect of pH on peroxidase-mediated oxidation of and DNA adduct formation by ellipticine
2006 |
Faculty of Science
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