Effects of hyaluronan and iodine on wound contraction and granulation tissue formation in rat skin wounds.
2010
Abstract
Hyaluronan plays an important role in the repair of damaged skin and has been used for the treatment of wounds. Iodine is a mild topical antiseptic.
A mixture of high molecular weight hyaluronan with iodine complex KI(3) (hyiodine) was reported to accelerate wound healing in patients with diabetes and patients after surgery. In our work, we investigated how this mixture effects wound contraction, granulation tissue and wound edges in excision skin wounds in rats.
Hyiodine accelerated wound contraction significantly in the firs 5 days of healing. Hyiodine supports wound healing by stimulating wound contraction, epidermal proliferation and by keeping the wound moist through increased exudation.