Methotrexate released in vitro from bone cement inhibits human stem cell proliferation in S/G2 phase

Abstract

Methotrexate (MTX) released from bone cement showed a useful local effect in animal models of bone tumours. However, local toxic reactions such as impaired wound healing were observed in areas surrounding the MTX – loaded implant.

Keywords

• Methotrexate loaded bone cement
• human stem cells