Chiral Separation of Binaphthyl Catalysts Using New Chiral Stationary Phases Based on Derivatized Cyclofructans
Abstract
Cyclofructans as a completely new and promising class of chiral selectors have been introduced last year for application in separation techniques such as liquid chromatography and capillary electrophoresis. Mainly derivatives of cyclofructans perform interesting separation possibilities for a variety of compounds.
The aromatic derivatized cyclofructans composed of six D-fructofuranose units (CF6) have exhibited the most interesting properties and unique enantioselectivity. In this work, two derivatized cyclofructan-based chiral stationary phases, RN-CF6 ( -naphthylethyl carbamate CF6) and DMP-CF7 (dimethylphenyl carbamate CF7) were used for enantioseparation of substituted binaphtyl catalysts, widely used to control asymmetric processes.
Normal separation mode, i.e. mobile phase composed of hexane and propane-2-ol in different ratios was applied and the enantioselectivity of the employed stationary phases was compared.