Abstract
The aim of this study was to evaluate the diagnostic yield of capsule endoscopy in nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy in pigs. Indomethacin (400 mg/day) was administered orally for 10 days to eight female pigs.
Afterwards, capsule endoscopy was performed, using the EndoCapsule system (OlympusOpticalCo., Tokyo, Japan). The following morning, pharmacological euthanasia and immediate autopsy were performed.
Small bowel injury compatible with NSAID-induced enteropathy was observed in 7/8 animals. The most common lesions were red spots and erosions.
Ulcers and small intestinal bleeding were identified sporadically. Sensitivity and specificity of capsule endoscopy were 83.3% and 95.8%, respectively.
Our results indicate that wireless capsule endoscopy is a highly accurate noninvasive method for evaluation of experimental NSAID-induced enteropathy.10.1007/s10620-009-1066-z