Low-Grade Cribriform Cystadenocarcinoma of the Parotid Gland: a Neoplasm With Favorable Prognosis, Distinct From Salivary Duct Carcinoma
Abstract
Low-grade cribriform cystadenocarcinoma (LGCCA) of salivary glands is recently described rare tumor with favourable prognosis. We report case of 50-year-old female with swelling lasting for 9 months in right parotideomasseteric area.
Grossly, the tumor was well circumscribed and dominated by cystic space. Microscopically, the neoplasm consisted of well demarcated islets, some of them cystically dilated.
The architecture of islets varied from solid to cribriform and micropapillary without comedo-type necroses. The tumor cells featured no cytologic atypia.
Immunohistochemically, luminal cells showed expression of cytokeratins (CK), CK7, CK18 and S100. Immunostains for CK5/6, CK14, p63 protein and smooth muscle actin displayed continuous rim of myoepithelial cells around all tumor nests.
Detection of CK20, hormonal receptors (androgen, estrogen and progesterone), EGFR and Her-2/neu oncoprotein was negative. The patient is free of disease for 2 years.