Publication at Faculty of Medicine in Hradec Králové |
2010
Abstract
Thioacetamid (TAA) is a hepatotoxin frequently used for experimental purposes, however the mechanism of its action has not been fully elucidated yet. Our results document that a profound reduction in the level of GSH precedes the rise in mitochondrial-dependent endogenous ROS, the disturbance in mitochondria metabolism, and cell death.