Role of cytochromes P450 and peroxidases in metabolism of the anticancer drug ellipticine: additional evidence of their contribution to ellipticine activation in rat liver, lung and kidney

Abstract

The paper describes role of cytochromes P450 and peroxidases in metabolism of the anticancer drug ellipticine and additional evidence of their contribution to ellipticine activation in rat liver, lung and kidney.

Keywords

• ellipticine
• anticancer drug
• DNA adduct
• cytochrome P450
• peroxidase