IL4 mediated transcriptional regulation of human CYP2E1 by two independent signaling pathways

Abstract

Cytochrome P450 2E1 (CYP2E1), the alcohol-inducible member of the cytochrome P450 super family, plays an important role in both physiological and pathophysiological processes. The present study focused on the induction of human CYP2E1 transcription by the anti-inflammatory cytokine interleukin-4 (IL-4) in human hepatoma B16A2 cells and revealed that this regulation is mediated by two independent pathways involving JAK-STAT6 and IRS1/2 and NFATc1.10.1016/j.bcp.2010.08.005

Keywords

• cytochrome P450 2E1
• B16A2 cell line
• Interleukin-4
• Transcriptional activation
• Transcription factors