Use of skin microcirculation examination in evaluation of the effectiveness of alprostadil in the therapy of non-healing skin ulcus cruris in kidney transplant recipient
2010
Abstract
The case report describes a male with transplanted kidney and non-healing chronic ischemic skin ulcus cruris. The skin defect did not heal, despite of complex revascularization, antibiotic and local therapy.
Administration of prostaglandin E1 (alprostadil) was therefore initiated. Positive effect of this therapy was verified during its first administration by measuring skin microcirculation using laser Doppler line scanner (LDLS).
After series of 20 alprostadil infusions, central necrosis was sequestered; ulcer began to granulate with reduction of its area and depth with tendency to healing.