Abstract
Infective endokarditis(IE) remains a very serious illness and neither the incidence nor the mortality have decreased in the past decades. Eradication of microbes by antimicrobial drugs is hte cornerstone of successful treatment.Antibiotic treatments should be targeted on the basic of positive blood cultures.Cell wall inhibitors in combination with aminoglycosides are used the most frequently.Surgery is indicated in approximately fifty percent of patients because of severe complications.Because of the complexity of that illness,mutispecialty approach is necessary.Updated recommendations for prevention of IE have dramatically changed lohg-established practise.Antibiotic prophylaxis is now advised only hor the highest risk patients undergoing the highest risk dental procedures.