Publication at First Faculty of Medicine, Faculty of Physical Education and Sport, Faculty of Medicine in Hradec Králové |
2011
Abstract
Visual functional impairment was studied using visually evoked and event-related potentials (VEPs and ERPs) in a group of ten patients with genetically verified spinocerebellar ataxia type 2 (SCA2). The motion-onset VEPs exhibited the highest sensitivity and showed a strong Spearman correlation to SCA2 duration (from r = 0.82 to r = 0.90, p { 0.001) and clinical state assessed by Brief Ataxia Rating Scale (from r = 0.71 (p = 0.022) to r = 0.80 (p { 0.001)).
The observed visual/cognitive deficit was not related to the genetic marker of SCA2.