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IRESite—a tool for the examination of viral and cellular internal ribosome entry sites

Publication at Faculty of Science, First Faculty of Medicine, Faculty of Mathematics and Physics |


The IRESite ( presents carefully curated experimental evidence of many eukaryotic viral and cellular internal ribosome entry site (IRES) regions. At the time of submission, IRESite stored `600 records.

The IRESite gradually evolved into a robust tool providing (i) biologically meaningful information regarding the IRESs and their experimental background (including annotation of IRES secondary structures and IRES transacting factors) as well as (ii) thorough concluding remarks to stored database entries and regularly updated evaluation of the reported IRES function. We also present a newly implemented tool for displaying RNA secondary structures and for searching through the structures currently stored in the database.