Publication
Abstract
Fever is part of the normal inflammatory response and most frequently occurs in response to infection. It is also often seen after vaccination, particularly in children following immunisation with diphtheria-tetanus-pertuses, measles and pneumococcal conjugate vaccines.
Prophylactic paracetamol administered during the first 24 hours significantly reduced febrile reactions reported within 4 days of vaccination but had no effect on the occurence of fever higher than 39,5 °C. However at same time GMCs and GMTs for a number of vaccine antigens were reduced in the group receiving prophylactic paracetamol compared to those not receiving paracetamol.