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Urinary neopterin, serum retinol, alpha-tocopherol and homocysteine in breast cancer patients during treatment with bevacizumab and chemotherapy

Publication at Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové |


We have studied serum homocysteine, C-reactive protein, alpha-tocopherol and retinol, and urinary neopterin in patients with metastatic breast cancer treated with bevacizumab, taxane and carboplatin. Homocysteine and C-reactive protein were determined immunochemically.

Alpha-tocopherol, retinol and urinary neopterin were determined by high performance liquid chromatography. Homocysteine, C-reactive protein and urinary neopterin decreased, while retinol and alpha-tocopherol increased during the therapy.

In conclusion, the treatment of patients with metastatic breast cancer with bevacizumab, taxane and carboplatin resulted in the suppression of systemic inflammatory and immune response.