Synthesis and study of properties of orthosubstituted 3-phenylisoalloxazines

Abstract

Atropoisomeric flavin salts with orthosubstituted phenyl group in position 3 are hopeful organocatalysts of enantioselectiv S and N oxidations used hydrogenperoxid or oxygen as stochiometric reagents. One of the synthetic possibilities of phenyl group installation to position 3 flavin molecule is the direct N-arylation, the second is gradual synthesis od flavin skeleton.

In this paper the preparation substituted falvin systems is discussed and also their distribution to enantionmers.

Keywords

• flavin salts
• enantionselectiv oxidations
• N-arylation
• enantiomer distribution