Rhodanineacetic acid derivatives as potential drugs: Preparation, hydrophobic properties and antifungal activity of (5-arylalkylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)acetic acids

Abstrakt

Some [(5Z)-(5-arylalkylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)]acetic acids were prepared as potential antifungal drugs. Lipophilicity of the compounds was analyzed using RP-HPLC and in silico methods.

All compounds were tested for antifungal effects against 8 fungal strains. One compound inhibited the growth of Candida spp. and Trichosporon asahii.

Klíčová slova

• [(5Z)-(5-arylalkylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)]acetic acids
• synthesis
• lipophilicity measurement
• in vitro antifungal activity