Abstract
The aim of our study was to assess whether the catechol-O- methyltransferase (COMT) genetic badkground of patients dependent on metaphetamine is related to their non-abstinence in a 1-year follow-up. We examined COMT gene Val158Met polymorphism and 1-year abstinence in a group of 31 (women N=8) Czech Caucasian metamphetamine abussers (average age, 23.8+-4.0 years).
Non-abstinence was significantly (P= 0.046, Fisher°s exact test) associated with the heterozygous Val/Met genotype.