Lithium microdialysis and its use for monitoring of stomach and colon submucosal blood perfusion - a pilot study using ischemic preconditioning in rats

Abstract

Ischemic preconditioning elevates nitric oxide and blood perfusion, whereby it protects organs against subsequent severe ischemia/reperfusion. Using a flow marker, microdialysis serves to monitor interstitial microcirculation.

This study tested the reliability of lithium as a flow marker on a model of ischemic preconditioning and found that lithium microdialysis appears to be a potentially suitable indicator of gastrointestinal interstitial microcirculation.

Keywords

• microdialysis
• microcirculation
• gastrointestinal tract
• ischemic preconditioning