Significance of genetic mutations and principle of disturbance of angiogenesis in renal cell carcinoma

Abstract

Primary mutation in some somatic cell is the reason for development of majority of tumors. The malignant transformation of cell consist of three steps: initialisation, promotion and progression.

Mutation of some gene results in loss or information of mutation product, that cause deregulation of cell proliferation, differentiation and apoptosis. Von Hippel-Lindau disease is an prototypical malignancy which is caused by mutation of tumor-suppressor gene.

Keywords

• mutation
• von Hippel-Lindau disease
• angiogenesis
• renal cell carcinoma
• hypoxia inducible factor