Abstract
In this study, global molecular changes associated with chronic anthracycline cardiotoxicity were analyzed for the first time using proteomic techniques. This approach identified 47 proteins significantly changed due to the treatment.
Important changes were found in mitochondrial oxidative phosphorylation and energy channeling, intermediate filament desmin, myosin light chains, proteolytic systems, chaperon proteins and many others. Furthermore, basement membrane and extracellular matrix remodeling was documented.
The above described changes were corroborated with other molecular and biochemical methods. Hence, in this study the proteomic signature of chronic anthracycline cardiotoxicity was described and it enhances understanding to the molecular basis of this iatrogenic disease.