The influence of PVA on the size of oligoester nanoparticles prepared by the emulsion solvent distribution method
2011
Abstract
Nanoparticles of poly(DL-lactic acid) (PDLLA) were prepared by the emulsion solvent distribution method. The external aqueous phase was composed of 1.5 and 3.0% solutions of three kinds of low molecular weight polyvinylalcohol (PVA) varying in molecular weight and saponification degree.
The internal oil phase was made from a 1% solution of PDLLA dissolved in dichloromethane, chloroform and a mixture of these two solvents. Viscosity and surface tension of these phases were not significantly influenced by the selected solvent or solute quality.
Contrary to these results, very different values of nanoparticle size were measured by the PCS method and the values of the zeta potential quantified by a laser Doppler velocimeter.