Studies on reduction of S-nitrosoglutathione by human carbonyl reductases 1 and 3

Abstrakt

The current study initially addressed whether CBR3 could equally reduce GSNO like CBR1 does. Neither the introduction of residues which contribute to glutathione binding in CBR1, nor the exchange C143S, which prevents a theoretical disulfide bond with C227 in CBR3, could engender activity towards GSNO.

Klíčová slova

• Carbonyl reductase
• S-nitrosoglutathione
• S-glutathionylation