Evaluation of mechanical resistance of tablets from recording force-path

Abstract

The paper evaluates the mechanical resistance of tablets by new parameters obtained from recording force-path relationship. The paper uses new parameters for the evaluation of dry binders for direct compression, microcrystalline cellulose, three lactose and calcium phosphate.

Keywords

• kinetics of crushing of tablets
• recording force-path
• crushing force DS
• path of crushing d
• rate constant of crushing process k
• deformation energy DE