Daunorubicin does not induce immunohistochemically detectable endothelial dysfunction in rabbit aorta and femoral artery

Abstract

In this study, we investigated whether rabbits exposed to a different cumulative dose of the anthracycline suffer from immunohistochemically detectable vascular toxicity and endothelial dysfunction.We have demonstrated that daunorubicin does not induce gross histopathological changes in studied arteries and it fails to induce immunohistochemically detectable endothelial dysfunction.

Keywords

• anthracyclines
• endothelial dysfunction
• immunohistochemistry
• rabbit
• aorta