Enhanced topical and transdermal delivery of antineoplastic and antiviral acyclic nucleoside phosphonate cPr-PMEDAP

Abstract

In vitro diffusion and metabolism of cPr-PMEDAP was investigated using formulations of different pH and concentration and with permeation enhancers through porcine and human skin.

Keywords

• acyclic nucleoside phosphonates
• antineoplastics
• antivirals
• permeation enhancer
• topical skin application
• transdermal delivery