Changes of cytokine levels during granulocytecolony-stimulating factor stem cell mobilization in healthy donors: association with mobilization efficiency and potential predictive significance

Abstract

Peripheral blood stem cells are an important source of hematopoietic stem cells (HSCs) for allogeneic transplantations. Some allogeneic donors mobilize HSCs poorly in response to the granulocytecolony-stimulating factor (G-CSF).

The estimation of the mobilization result in an individual donor is difficult due to the absence of suitable predictive factors. We analyzed the concentrations and kinetics of certain cytokines induced by G-CSF in 76 healthy donors and compared them with the mobilization efficiency.

Keywords

• factor g-csf
• peripheral-blood
• adhesion molecules
• cd34(+) cells
• bone-marrow
• hematopoietic stem
• progenitor cells
• hodgkins-lymphoma
• l-selectin
• expression