Inhibition of lysosomal degradation rescues pentamidine-mediated decreases of K(IR)2.1 ion channel expression but not that of K(v)11.1

Abstract

Pentamidine disrupt trafficking of two structurally different potassium channels, which can precipitate life-threatening arrhythmia. We demonstrate that a single drug can interfere in cardiac potassium channel trafficking in a subtype specific mode and that this adverse drug effect can be corrected in a channel specific manner.

Keywords

• pentamidine
• K(IR)2.1
• hERG
• potassium ion channel
• trafficking
• lysosome