The anti-protozoal drug pentamidine blocks K(IR)2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel
2010
Abstract
Pentamidine treatment may cause sudden cardiac death by provoking cardiac arrhythmias. It is known that pentamidine disrupt trafficking of hERG potassium channel.
Here we demonstrate direct interaction of pentamidine with KIR2.X channel resulting in functional block of IK1 current.