Abstract
Pancreatic fistula is a major postoperative complication after pancreatic resection. One of the main risk factors of developing the pancreatic fistula after distal pancreatectomy in the method employed for the management of the pacreatic remnant.
The aim of the experimental part of work was to test a novel method of management of the pancreatic remnant after distal pancreatectomy on a large laboratory animal. Furthemore, based on the experience with the experimental work to introduce the laparoscopic approach to human clinical practice.
In the experimental part of the work the postoperative course was uneventful in all the animals.Only minor macroscopic and microscopic alterations of the healing process were found. In the experimental part of the work we showed that the novel technique using Ligasure transection reinforced by the hydrogel sealant Pleuraseal is feasible and safe technique, which seems to be comparable with the standard transection technique using stapler.