Statins and their influence on brain cholesterol

Abstrakt

Growing evidence suggests that different statins are able to lower brain cholesterol synthesis. It is clear yet whether lipophilic statins influence brain cholesterol in different way than hydrophilic ones.

Better understanding of the effects of statins on brain metabolism becomes more important because many studies bring evidence of a possible link between cholesterol and neurodegeneration.

Klíčová slova

• blood-brain barrier
• brain cholesterol
• 24S-hydroxycholesterol
• lathosterol
• statins