TRAP, a Powerful and Versatile Framework for Gallium-68 Radiopharmaceuticals

Abstract

Triazacyclononane-phosphinic acid chelators (TRAP) form highly stable complexes with Ga(3+) extremely efficiently over a wide pH range. Homo- and heteromultimeric bioconjugates can be easily synthesized.

TRAP are rendered a chelator with ideal properties for (68)Ga positron emission tomography (PET) imaging agents development.

Keywords

• TRAP
• phosphinic ligands
• gallium-68
• macrocyclic ligands
• molecular imaging
• positron emission tomography
• radiopharmaceuticals
• peptides
• tacn derivatives
• multimeric agents