Activation and Regulation of Purinergic P2X Receptor Channels

Abstract

Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven possible subunits, denoted P2X1 to P2X7. In this paper, we discuss data obtained from numerous site-directed mutagenesis experiments of P2X channels accumulated during the last 15 years with reference to the crystal structure, allowing a structural interpretation of the molecular basis of orthosteric and allosteric ligand actions.

Keywords

• gated ion channels
• root ganglion neurons
• amino-acid-residues
• protein-kinase-C
• pig urinary-bladder
• messenger-RNA expression
• anterior-pituitary-cells
• ATP-induced currents
• negatively charged residues
• first transmembrane domain