Publication at Faculty of Medicine in Hradec Králové |
2011
Abstract
To assay drug resistance/sensitivity by MTT test in solid tumor or ascitic fluid in ovarian cancer patients. The highest frequency of resistance in vitro occured for etoposid, gemcitabin and paclitaxel and the most effective chemotherapeutical agents in vitro were cisplatinum and topotecan.
Cisplatin had the lowest incidence of drug resistance in vitro than carboplatin. Resistance/sensitivity assay would contribute for targeted treatment in ovarian cancer patients.