Deteriorating effect of fluvastatin on the cholestatic liver injury induced by bile duct ligation in rats
2011
Abstract
Fluvastatin (1 or 5 mg/kg) was administered after surgery and then daily for 7 days. The dose of 5 mg/kg led to the deterioration of hepatocellular injury.
Despite lower production of IL-6, decrease in GSH content, rise of TGFbeta and inhibiton of respiratory complex I in mitochondria were determined. The mRNA expressions of canalicular transporter Mdr1b and basolateral transporter Mrp3 increased in cholestatic liver.
Fluvastatin administration then led to the attenuation of this change. Analogously, mRNA expression of cunjugative enzyme Ugt1a1 was diminished by fluvastatin administration to cholestatic rats.