Abstrakt
The aim of experiment was to follow the effect of atorvastatin on bone metabolism in male rats. Our study was carried out on 16 rats.
The control group (CO) was given aqua pro injectione (0.2 mL/100 g BW; gavage) and the experimental group atorvastatin suspension (AT; 0.3mg in 0.2mL aqua pro inj./100 g BW; gavage) for 8 weeks. We examined serum markers of bone turnover using ELISA - C-terminal crosslinking telopeptide of type I collagen, osteocalcin, procollagen type I N propeptide and bone alkaline phosphatase (BALP).
We investigated bone morphogenetic protein-2 (BMP-2) in the proximal tibia using Western blot analysis. We measured bone mineral density.
The femurs were used for a biomechanical testing. After 8 weeks of atorvastatin administration, a significant decrease was found in serum level of BALP to 30% vs.
CO (p = 0.005). The expression of BMP-2 was increased.
Atorvastatin influenced bone metabolism by decreasing BALP, and probably in consequence increasing expression of BMP-2 in rats.