A comparative study of pharmacokinetics, urinary excretion and tissue distribution of platinum in rats following a single-dose oral administration of two platinum(IV) complexes LA-12 (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloro platinum(IV) and satraplatin (OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum(IV)
2011
Abstrakt
The study compared the pharmacokinetics, tissue distribution, and urinary excretion of platinum in rats after single oral doses of LA-12 and satraplatin. Characteristics of platinum exposure evaluated in the plasma, plasma ultrafiltrate and kidney and liver tissues.
In the dose range of 37.5-300mg/kg, platinum concentrations increased less than in the proportion to the dose and, the fraction of dose exctreted in urine decreased. For both drugs, a dose-related decrease in the extent of oral bioavailability was observed most likely due to saturable intestinal absorption.