Prolonged morphine administration alters protein expression in the rat myocardium

Abstrakt

The aim of the study was to identify the presumed alterations in rat myocardial protein levels after prolonged morphine treatment (10 mg/kg, 10 days). Nine proteins were found to show markedly altered expression levels in samples from morphine-treaded rats and these proteins were identified by mass spectrometric analysis.

They belong to different cell pathways including signaling, cytoprotective, and structural elements.

Klíčová slova

• Heart
• morphine
• myocardial protein