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Sarcopenia - brief characteristics, etiology and possible therapy

Publication at Faculty of Physical Education and Sport |
2012

Abstract

Sarcopenia is considered to be a geriatric syndrome with multifactorial etiology: mitochondrial dysfunction, replication defects in mitochondrial DNA that lead deficit in energy production and muscle fibre atrophy, changes in protein synthesis, imbalance between protein degradation and the ability of muscle fibre to new proteins synthesis, changes in secretion and plasmatic levels of hormones (growth hormone, androgens, insulin etc.), metabolic syndrome or imbalance in antioxidant system and many more (Buford, et al., 2010). We are still far from being able to fully understand the causes and characteristics of sarcopenia as well as to solve this problem.

However, an appropriate lifestyle (movement activity) and appropriate diets (energy restriction) seem to be the most effective therapeutic approaches (Morley, et al., 2010).