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18F-FDG-PET/CT in renal-cell carcinoma

Publication at First Faculty of Medicine, Faculty of Medicine in Pilsen, Central Library of Charles University |
2011

Abstract

The analysis of the sample of 40 patients was made; it consists of 28 males, 12 females, mean age 67.8 years, ranging 53-86 years. All patients underwent 18F-FDG-PET/ CT including two-phase CT-angiography of the kidneys, locally advanced or generalized renal cell carcinoma was suspected in all patients.

The level of the 18F-FDG accumulation within the tumor was compared with the histological grading and the development of the disease was surveyed twelve months after 18F-FDG-PET/CT. Overall mortality reached 45%, the highest 18F-FDG accumulation showed tumor of the grade 4 (mean SUV 10.4, ranging 5-22), the highest mortality was present in tumors exceeded the SUVmax value of 10 (mortality 63.6%).

New information was brought by 18F-FDG-PET/CT in comparison to CT in 87.5%. 18F-FDG-PET/CT is useful tool to make decision about the way of treatment especially when the generalization is confirmed or excluded; the method is bearing the potential to set the prognosis according the reached value of 18F-FDG accumulation measured in SUVmax.