The avidity of anti-Beta2-glycoprotein I antibodies in patients with or without antiphospolipid syndrome: a collaborative study in the frame of the European forum on antiphospolipid antibodies

Abstract

Patients with or without APS had anti-β2-GPI of high, low or heterogeneous avidity. High avidity anti-β2-GPI was associated with thrombosis and APS, while in the low avidity anti-β2-GPI group non-APS (predominantly SLE) patients prevailed.

Determination of anti-β2-GPI avidity should be considered in the analytical strategies for further differentiation of patients with anti-β2-GPI antibodies

Keywords

• anti-Beta2-glycoprotein
• antibodies
• avidity
• chaotropic test
• multicentric study
• thrombosis