Publication at Faculty of Medicine in Hradec Králové |
2011
Abstract
Inadequate platelet suppression by acetylosalicylic acid is a relavively well known phenomenon in cardiology. How to define it properly? Persistent high residual platelet reactivity or treatment failure seems to be the best term.
There are several reasons for an inadequate platelet suppression and several techniques may be used to assess platelet function and the effectiveness of antiplatelet therapy. The role of inflammation and genetic polymorphisms in high residual platelet activity and atherothrombosis was studied with inconsistent results.
There are still no clinical data to support change in antiplatelet therapy in the correlation with laboratory results in patients with coronary artery disease.