Good short-term but not long-term reproducibility of the antiplatelet efficacy laboratory assessment
Abstrakt
Background: The antiplatelet effect of acetylsalicylic acid (ASA) varies among individual patients. We assessed the short-term (STR) and long-term reproducibility (LTR) of light transmission aggregometry (LTA).
Methods: Residual platelet reactivity was measured twice using LTA in a group of 207 consecutive patients (56 females, mean age 67+-9 years) on ASA therapy in 10 +- 6 months interval. STR was assessed in 15 patients (6 females, mean age 61 +- 7 years) with 10 measurements on 2 consecutive days.
Results: There was no correlation between both measurements in the long-term part of the study and also Bland Altman plot showed a diverging pattern. However, LTA STR was good with a correlation coefficient of 0.800 (p{0.05), confirmed by Bland Altman plot.
Conclusions: Whereas short-term intraindividual reproducibility of LTA assessment of platelet reactivity is very good, in the long term perspective the antiplatelet ASA effectivity may be influenced by additional variables and repeated measurements are warranted.