High-performance liquid chromatographic determination of tiapride and its phase I metabolite in blood plasma using tandem UV photodiode-array and fluorescence detection

Abstrakt

New bioanalytical SPE-HPLC-PDA-FL method for the determination of the neuroleptic drug tiapride and its N-desethyl metabolite was developed, validated and applied to xenobiochemical and pharmacokinetic studies in humans and animals.

Klíčová slova

• benzamide neuroleptics
• tiapride
• N-desethyl tiapride (metabolite)
• human pharmacokinetics
• HPLC with UV photodiode-array and fluorescence detection