Correlation of peripheral blood CD14+CD16+ monocytes, urinary neopterin and the risk factors of atherosclerosis in patients with breast carcinoma
Abstract
Monocytes/macrophages are thought to play a fundamental role in the development of vascular lesions in atherosclerosis. In the present study, we evaluated circulating CD14+CD16+ monocytes, laboratory parameters of the risk of atherosclerosis, including serum cholesterol, homocysteine and C-reactive protein, urinary neopterin, serum α-tocopherol and retinol along with carotid intima-media thickness in patients with breast carcinoma.
A significant correlation was observed between the absolute numbers of CD14+CD16+ monocytes, serum HDL cholesterol and triglyceride concentrations. In conclusion, present data extend the observation of an association between peripheral blood CD14+CD16+ monocyte counts and lipid metabolism to cancer patients.
No correlation of CD14+CD16+ monocyte counts with urinary neopterin concentrations was observed.