Publikace na Přírodovědecká fakulta |
2011
Abstrakt
Minimal inhibitory concentrations (MICs) against different Candida species (C. albicans, C. krusei, C. glabrata, C. tropicalis and C. parapsilosis) of recently isolated, synthesized and characterized antimicrobial α-helical amphipathic peptides (12-18 amino acids long) from the venom of hymenoptera (melectin, lasioglossins I, II, and III, halictines I and II) as well as a whole series of synthetic analogs were determined. In the case of the natural peptides they amounted to 4-20 μM (7-40 mg/l).
The most active ones were the synthetic analogs all-D-lasioglossin III and KNWKK-Aib-LGK-Aib-IK-Aib-VK-NH2.