The Influence of Vascular Endothelial Growth Factor (VEGF) Polymorphism on the Progression of Chronic Glomerulonephritides

Abstract

Vascular endothelial growth factor is an important mediator in maintaining normal kidney functions. We have not proved any significant influence of the polymorphisms at positions -2578 C/A and -1154 G/A of the vascular endothelial growth factor gene promoter on the progression of chronic glomerulonephritides even though our study suggests a negative effect of CC genotype of -2578 C/A polymorphism on the clinical course of minimal change disease/focal segmental glomerulosclerosis.

Keywords

• vascular endothelial growth factor
• IgA nephropathy
• focal segmental glomerulosclerosis
• membranous glomerulonephritis
• gene promoter polymorphism